弗莱德·麦克莫瑞

Fred MacMurray

饰：Meriwether Lewis

查尔顿·赫斯顿

Charlton Heston

饰：William Clark

唐娜·里德

Donna Reed

饰：Sacajawea

芭芭拉·海尔

Barbara Hale

饰：Julia Hancock

威廉·德马雷斯特

William Demarest

饰：Sgt. Cass

艾伦·里德

Alan Reed

饰：Charboneau

拉里·彭内尔

Larry Pennell

饰：Wild Eagle

Herbert Heyes

饰：President Jefferson

莱斯特·马修斯

Lester Matthews

饰：Mr. Hancock

阿亨蒂娜·布鲁内蒂

Argentina Brunetti

饰：Old Crone

Julia Montoya

饰：Crow woman

Ralph Moody

饰：Le Borgne

沃尔特·里德

Walter Reed

饰：Cruzatte (helmsman)

海伦·华莱士

Helen Wallace

饰：Mrs. Hancock

Joe Canutt

饰：Bit part (uncredited)

Frank Fowler

Frank Fowler

饰：Bit part (uncredited)

Bob Herron

饰：Bit part (uncredited)

比尔·希克曼

Bill Hickman

饰：Member of the expedition (uncredited)

Leroy Johnson

饰：Bit part (uncredited)

Margarita Martín

饰：Bit part (uncredited)

汤姆·梦露

Tom Monroe

饰：Bit part (uncredited)

Voltaire Perkins

饰：Bit part (uncredited)

威廉·菲普斯

William Phipps

饰：Oarsman (uncredited)

Vernon Rich

饰：Bit part (uncredited)

Herman Scharff

饰：Bit part (uncredited)

比尔·沃克

Bill Walker

饰：Tom (servant) (uncredited)

Al Wyatt Sr.

饰：Bit part (uncredited)

爱德华多·诺列加

Eduardo Noriega

饰：Cameahwait

Robert Hinkle

Robert Hinkle

Fran Bennett

Francesca Bennett

阿特·吉尔摩

Art Gilmore

查尔登·海斯顿

Charlton Heston